Oral Histology & Development


  • Undifferentiated ectomesenchymal cells (Inner enamel epithelium) differentiate into pre-ameloblasts
  • Pre-ameloblast:

Secretes growth factor which excites dental papillary cells
Cells go under mitosis, mitotic spindles are perpendicular to the basement membrane
  • Mitosis forms odontoblast and sub-odontoblast cells
  • Sub-odontoblast are responsible for reparative dentine
  • Basement membrane disintegrates 
  • Pre dentine is formed
  • Full thickness of primary dentine present

Comparison: Primary and Secondary Dentine

Comparison: Primary and Secondary Curvatur